Bone tissue is made up of 70% inorganic components (45% mineral salts and 25% water) and 30% organic matrix. The 90% of this organic matrix is type I collagen to which the calcium salts are attached.

The special bond between collagen and calcium salts provides the bone a characteristic toughness and mechanical resistance.

During aging, the loss and deterioration of bone collagen causes the release of calcium salts (decalcification). Consequently, bone mass is reduced, and the bone becomes more fragile, increasing the risk of fracture.

When this process causes a marked and pathological loss of bone mass, it is called osteoporosis (OP), a silent disease until a fracture occurs. OP affects more women after menopause because the decrease in the level of estrogens slows down the synthesis of collagen1.

At this point, supplementing the diet with only calcium and vitamin D is not enough help because the calcium salts cannot reattach to the bone if its collagenous matrix does not have enough collagen fibers to adhere to.

That is why we need a supplement composed of specific nutrients that reinforce both the mineral and collagenous part of the bone.

PHOSCOLLAGEN® is a high bioavailable hydrolysed collagen-hydroxyapaptite complex that perfectly fulfills the objective of helping to reinforce -strengthen- the bone, since it is made up of the same bone components (collagen, calcium and phosphorus) converted into highly assimilable nutrients that are easy and pleasant to take:

 

Scientific studies describe the mechanism of action and beneficial effects of hydrolyzed collagen on bone metabolism:

  • Bioactive peptides stimulate the activity of osteoblasts, the cells responsible for the formation of collagenous matrix and its subsequent mineralization;
  • Amino acids provide the basic structural units that osteoblasts need to synthesize the collagenous matrix that will support the mineral salts.

In this way, hydrolyzed collagen stimulates and facilitates bone formation3-5. From these and other studies, it follows that hydrolyzed collagen is useful for the prevention and management of bone loss6.

Hydroxyapatite is the specific form of calcium phosphate found in bones therefore it provides the right ratio (physiological ratio) between calcium and phosphorus (Ca/P = 2,15), to allow mineralization of the bone collagenous matrix and prevent its decalcification, a risk that exists when phosphorus reaches higher proportions.

Studies carried out with hydroxyapatite have shown that it prevents the loss of bone mass in patients treated with corticosteroids, drugs with an increased risk of fractures7 as side effect.

Studies using hydroxyapatite combined with a protein component have also yielded good results, showing its superiority over other calcium salts8.

In addition to hydrolyzed collagen studies, on the one hand, and hydroxyapatite studies, on the other, on bone health beneficial effects, there are also clinical studies on postmenopausal women9-11 and on children12 that analyze the combined action of hydrolyzed collagen plus calcium and vitamin D. These studies reveal that there is a significant improvement in results when, in addition to calcium and vitamin D, hydrolyzed collagen is included in the treatment.

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BIBLIOGRAPHY

1. Aurégan, JC., et al. “Correlation between skin and bone parameters in women with postmenopausal osteoporosis: a systematic review” EFORT Open Rev 2018;3:449-460.
2. Zeijdner E.E. “Digestibility of collagen hydrolysate during passage through a dynamic gastric and small intestinal model (TIM-1) “. TNO Nutrition and food Research Report. 24 June 2002
3. Wauquier, F., et al. “Human Enriched Serum Following Hydrolysed Collagen Absorption Modulates Bone Cell Activity: from Bedside to Bench and Vice Versa” Nutrients 2019, 11, 1249
4. Guillerminet F. «Collagène hydrolysé et santé osseuse» Alimentation et Nutrition. AgroParisTech, 2010.
5. Daneault, A., et al. (2017) “Biological effect of hydrolyzed collagen on bone metabolism” Critical Reviews in Food Science and Nutrition, 57:9, 1922-1937
6. Porfírio E, Fanaro GB (2016) “Collagen supplementation as a complementary therapy for the prevention and treatment of osteoporosis and osteoarthritis: a systematic review” Revista Brasileira de Geriatria e Gerontologia 19: 153-164
7. Pines, A., Raafat, H., Lynn, A. H. & Whittington, J. “Clinical trial of microcrystalline hydroxyapatite compound (‘Ossopan’) in the prevention of osteoporosis due to corticosteroid therapy”. Curr. Med. Res. Opin. (1984)
8. Castelo-Branco, C. et al. “Efficacy and safety of ossein-hydroxyapatite complex versus calcium carbonate to prevent bone loss”. Climacteric (2019)
9. Hooshmand, S. et al. “Evidence for Bone Reversal Properties of a Calcium- Collagen Chelate, a Novel Dietary Supplement” J Food Nutr Disor 2013, 2:1
10. Elam, ML. et al. “A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial” J Med Food 00 (0) 2014, 1–8
11. Argyrou, Chrysoula et al. “Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia”. Journal of musculoskeletal & neuronal interactions vol. 20,1 (2020): 12-17.
12. Martin-Bautista, E. et al. “A nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modelling biomarkers” J Pediatr Endocrinol Metab. 2011;24(3-4):147-53.

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